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The Food and Drug Administration has seen a sharp increase in applications for drug to treat rare diseases. An oversight report found problems with how agency is handling them.

FDA Faulted For Lapses In Orphan Drug Program

The Government Accountability Office found breakdowns in the way the Food and Drug Administration evaluates drugs for rare diseases. The analysis came after an investigation by Kaiser Health News.

Workers in dust masks wash fresh red bell peppers in smoky conditions outside of Eltopia, Wash. Even with the masks, the smoke is still causing tight chests, itchy eyes and dry throats.

As Wildfires Rage, Smoke Chokes Out Farmworkers And Delays Some Crops

Smoke from wildfires is blanketing much of the West. That's ruining some crops and may be stunting others. And it's making it difficult or unsafe for laborers to pick the harvest.

Trinidad and Tobago's Alvin Jones (17) celebrates after scoring against the U.S. Tuesday, in a game that served as revenge for his team's 1989 loss to the Americans. The U.S. men are eliminated from the 2018 World Cup.

'Revenge,' Shock And Rage, After U.S. Men's Team Whiffs On World Cup

"We can't beat Trinidad," commentator Taylor Twellman said, before asking, "What are we doing? ... What are we doing?!?!"

Puerto Rican chef Jose Sanchez inside his restaurant Pera Maraya. "Everything was going perfect," says Sanchez, 28. "Then the storm hit."

Don't Surrender, Reinvent: The New Mantra Of Small Biz In Puerto Rico

Facing an uncertain future and dim prospects of financial relief, small businesses get support and strength from each other.

Lt. Gen. Mohamed Hamdan Dagalo is a social media personality. He's also the leader of the paramilitary group that attacked thousands of pro-democracy protesters on June 3, leaving more than a 100 dead.

Why Facebook Won't Kick Off A Warlord

Facebook banned far-right extremist Alex Jones. But it won't remove from the platform the warlord Lt. Gen. Mohamed Hamdan Dagalo, even though he oversaw the killing of more than 100 people in Sudan.

Women In National Security Push To Move Beyond 'The First' And 'The Only'

For years, women have fought for inclusion in the high-stakes world of national security. Now, they say, the effort to build a pipeline of qualified women leaders is paying off.

Concert-Goer Describes Deadly Scene After Mass Shooting In Las Vegas

Mark Lacy, an audience member in the VIP section at the Harvest Festival in Las Vegas, witnessed the shooting at close range, and he even stood next to someone shot in the head. NPR's Robert Siegel talks to Lacy, who stayed on the scene well into the early morning hours helping the injured.

Week In Politics: Republican Efforts To Overhaul The Tax Code

NPR's Ailsa Chang speaks with E.J. Dionne of The Washington Post and the Brookings Institution, and David Brooks of The New York Times, about Republican leadership's bad week and the rollout of a Republican effort to overhaul the tax code.

North Korean leader Kim Jong Un waves during a parade in Pyongyang in October. The country has carried out a series of provocative actions recently, though Kim's motives are not clear.

As North Korea Acts Out, A Search For Kim Jong Un's Motives

The isolated nation has undertaken a series of provocative steps, launching missiles and bombastic rhetoric. Analysts are debating what leader Kim Jong Un is trying to achieve.

Eduardo Martinez shares a picture of himself as Samantha (in the blond wig).

Love, Loss And Beauty Pageants: Inside A Cuban HIV Sanitarium

The "Christian Dior Of Cuba" looks back on bittersweet memories from his time living in a housing facility for people with HIV.

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