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Late Show host David Letterman said goodbye Wednesday night with his trademark self-deprecating sarcasm. He left as he had arrived: with a hilarious show made on his own terms.

Hillary Clinton's campaign went into overdrive Tuesday, trying to minimize damage from a new book that delves into Clinton foundation fundraising — and it's not using the typical channels to do so.

The term dates back to the 19th century when white traders would swap "firewater" for Indian goods and "off the reservation" was "a lonely and dangerous place for an aboriginal American to be."

About 75,000 patients a year die from infections they caught in the hospital. A Kaiser Health News analysis finds that nearly 700 hospitals across the nation have higher than expected infection rates.

Some of the most interesting things on TV in 2014 weren't actually made for TV. NPR TV critic Eric Deggans lists the moments in television, viral video and social media that changed us all this year.

Zappos.com CEO Tony Hsieh pumped $350 million into downtrodden downtown Las Vegas to make it a home for startups and a place young people want to live again. Three years in, is it working?

It was a good day for complicated male leads and the movies that feature them, and a rough day for just about everybody else at the Oscar nominations.

The Common Core State Standards are changing reading instruction in many schools. And that means new challenges for lots of students, even traditional high achievers.

The Millennium Development Goals, set in 2000, revolutionized the fight against poverty. Now the world is setting Sustainable Development Goals. But critics say there may be too many priorities.

California is trying to do just that, though police and advocates for ex-offenders are at odds over whether it will work. The debate is playing out as President Obama is calling for nationwide change.