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The most powerful hurricane ever recorded in the eastern Pacific will make a "potentially catastrophic landfall" in southwestern Mexico Friday, the National Weather Service says.

The mishaps mean federal scientists need to "take a hard look" at all federal research on deadly pathogens and make sure, in each case, that the benefits justify risks, says Dr. Tom Frieden.

Some argue that workers should be able to move more freely in a global economy. But others push back, saying an influx of labor into the richest countries would devalue workers' worth and actually hurt more in the long run. A group of experts debates for Intelligence Squared U.S.

Sophie Varon loves to shop. The store Forever 21 is her weakness. And lately, she's been wondering if her shopping habit has become a shopping problem.

Coach Jürgen Klinsmann's squad beat Guatemala 4-0 to advance to the next round of qualifying matches for the 2018 World Cup. The win also may quell calls for Klinsmann to be fired.

David Greene talks with Sylvain Groulx, head of mission for Doctors without Borders in the Central African Republic, about the state of the violence there and the hopes for peace now that French troops have arrived.

The Affordable Care Act's rollout has taken the remarkable Democratic Party unity that existed during the government shutdown and smashed it to smithereens.

Medical tourism was expected to be huge in 2013, and countries like Colombia, which has seen huge improvements in safety and tourism, decided they wanted in on the action. In recent years they've been building facilities specifically designed for medical tourists. But the numbers have not quite met projections.

As early as September new Internet suffixes — from .nyc to .google to .ngo — will begin rolling out. It's a controversial plan that raised concerns about fraud, trademark infringement and customer confusion, but the Web's governing body says those issues have been addressed.

Dozens of supporters of deposed President Mohammed Morsi were shot by security forces Saturday. Guest host Linda Wertheimer talks to NPR's Soraya Sarhaddi Nelson about the latest from Egypt.