The COVID death toll in Vanderburgh County has reached 120, while deaths have spiked in western Kentucky.
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The Indiana State Department of Health reported five more COVID-related deaths in the county, along with more than 200 new infections.
The department also announced the 19th COVID death in Pike County.
The agency did not record any fatalities in Warrick, Posey, or Gibson counties on its Wednesday dashboard.
273 COVID patients were hospitalized in southwest Indiana, with the percentage of available intensive care beds down to 15.5 percent in the 12-county region.
Statewide, the agency announced 63 new COVID-related deaths and more than 6,000 new infections.
In western Kentucky, the Green River District Health Department announced nine new fatalities, three of them in Henderson County, three in Daviess County, two in McLean County, and one Ohio County.
The department reported 171 new infections and 54 hospitalized COVID patients in the seven-county district.