The Vanderburgh Humane Society says it sheltered more than 3,400 animals last year.
The society said it took in 500 more animals than in the previous three years.
In a news release, the not-for-profit said nearly 2500 animals were adopted, with more than 200 of them adopted at the River Kitty Café in Downtown Evansville.
The VHS said 324 animals had to be euthanized, but none were put down because of a lack of space.
The agency also said there are still animals that arrive at shelters with severe, life-threatening diseases. There are also animals with behavior or aggression problems that would be considered unsafe in almost any home.